Shock & arcing risk  — How will increasing voltage affect protection at the connection?

Safe hot-swapping  — Does the connection need to support safe mating or unmating while the system is energized?

Touch protection  — Does the design need to help prevent accidental contact with energized conductors?

Service isolation  — How will power be safely disconnected and de-energized during maintenance?

Backplane mating points  — Are additional modules increasing the number of power and signal connections?

Tolerance stack-up  — Can the connection accommodate alignment variation across modular assemblies?

Blind mating  — Do modules need to connect reliably where direct alignment or visibility is limited?

Cable reduction  — Can branch connections reduce cabling and save space within the system?